Bio-Quinone Q10. Also known as ubiquinone, or simply vitamin Q, coenzyme Q10 is a lipid type structure with vitamin like activity. It is found naturally occurring in all human cells, and is responsible for the cells energy production. As we get older Q10 levels fall off, making supplementation necessary.Coenzyme Q10 functions at a very fundamental level as a carrier in the "electron transport" chain. This is the final stage of a very complex process in which energy is produced from food, leading to the production of Adenosine Tri-phosphate, ATP. It is ATP that the cell uses as a "fuel".Coenzyme Q10 has been used in the management of a variety of disorders. Its primary use is as an adjunctive therapy for chronic heart failure. It has been shown to be effective in the management of congestive heart failure, cardiomyopathy, hypertension, stable angina, ventricular arrhythmia, cancer, periodontal disease, chronic fatigue, muscular dystrophy, and as a general energy booster.Coenzyme Q10 is usually effective at levels of 60-100mg/day in healthy individuals. When used therapeutically doses of 100-600mg/day should be taken. Up to 800mg have been used in long term studies without any toxicity problems or side effects.Coenzyme Q10 comes in a variety of forms, ie. tablets, capsules containing oil, capsules containing granulates. The most bio-available form is when the coenzyme Q10 is dissolved in soya bean oil and presented in a gelatine capsule as in Bio-Quinone Q10 (Pharma Nord). This particular form has the greatest bio-availability (absorption) in the body.There are a great many scientific papers that show the beneficial effects of coenzyme Q10, particularly in the field of heart disease. There are no known interactions or contra-indications with coenzyme Q10. Pharma Nord recommends 60-100mg of Bio-Quinone Q10 per day, to be taken with food to enhance absorption.
There are no known interactions or contra-indications with Pharma Nord Bio-Quinone Q10.Pharma Nord Bio-Quinone Q10 can't be overdosed.
Pregnant and lactating women and those on medication should seek professional advice prior to taking Pharma Nord Bio-Quinone Q10.
How much should I take? The generally recommended intake for coenzyme Q10 is 30 to 200mg/day, taken with meals, to enhance absorption.
What are statins? Statins are a class of cholesterol-lowering drugs that work by inhibiting the enzyme HMG-CoA reductase, which is plays a central role in the liver’s synthesis of cholesterol. Randomized clinical trials (RCT) show that statins are most effective when given to patients who already suffer from cardiovascular disease (CVD). They are, however, also widely used without CVD but who suffer from elevated cholesterol levels and/or other risk factors like diabetes and hypertension. There are many different types of statins, some with a more potent LDL-lowering effect than others.
How do statins work? Statins inhibit the enzyme HGM-CoA reductase and its ability to produce mevalonate, which is an intermediate product in the multi-step synthesis of cholesterol. In what is often referred to as the mevalonate pathway, mevalonate would under normal circumstances undergo a number of biochemical transformations, eventually causing it to branch into several different compounds, including cholesterol and ubiquinone. Statins effectively block this process.
Q10 and Cholesterol
Since coenzyme Q10 and cholesterol are both synthesized from the same substance, mevalonate, this implies that if the body's production of cholesterol is reduced by a statin, the body's production of coenzyme Q10 is reduced accordingly. Coenzyme Q10 has multiple effects on the body's cholesterol level. Coenzyme Q10 will lower the body's cholesterol levels marginally. In addition, the antioxidant effect of Q10 will prevent circulating cholesterol from oxidizing and becoming very harmful.